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Ammon News - The Friends actor died due to acute effects of ketamine, according to an autopsy report obtained by PEOPLE. Drowning, coronary artery disease and buprenorphine effects (a medication used to treat opioid use disorder) were also listed as contributing factors in his death, which was ruled accidental.

Ketamine is a "dissociative anesthetic that has some hallucinogenic effects," per the US Drug Enforcement Administration. It "distorts the perception of sight and sound and makes the user feel disconnected and not in control," and "can induce a state of sedation (feeling calm and relaxed), immobility, relief from pain, and amnesia."

The autopsy states that Perry — who was "reportedly clean for 19 months" — was on ketamine infusion therapy, with his latest treatment taking place just "one and a half weeks before" his death. However, the coroner noted that "the ketamine in his system at death could not be from that infusion therapy, since ketamine's half-life is 3 to 4 hours, or less."

Per the autopsy, Perry's death occurred by "unknown route of drug intake." The coroner stated that Perry was found "in a residential pool," with prescription medications and loose pills present at his residence but "none reported near the pool" or "adjacent to the pool." The autopsy also notes that there were "no signs of fatal trauma or no foul play suspected."

Perry died Saturday, Oct. 28 at his Los Angeles home. He was 54.

People