Ammon News - Iran's Supreme Leader Ayatollah Ali Khamenei said on Wednesday that abandoning uranium enrichment was "100%" against the country's interests, rejecting a central U.S. demand in talks to resolve a decades-long dispute over Tehran's nuclear ambitions.

The U.S. proposal for a new nuclear deal was presented to Iran on Saturday by Oman, which has mediated talks between Iranian Foreign Minister Abbas Araqchi and President Donald Trump's Middle East envoy, Steve Witkoff.

After five rounds of talks, several hard-to-bridge issues remain, including Iran's insistence on maintaining uranium enrichment on its soil and Tehran's refusal to ship abroad its entire existing stockpile of highly enriched uranium - possible raw material for nuclear bombs.

Khamenei, who has the final say on all matters of state, said nothing about halting the talks, but said the U.S. proposal "contradicts our nation's belief in self-reliance and the principle of 'We Can'".

"Uranium enrichment is the key to our nuclear programme and the enemies have focused on the enrichment," Khamenei said during a televised speech marking the anniversary of the death of the Islamic Republic's founder, Ayatollah Ruhollah Khomeini.

"The proposal that the Americans have presented is 100% against our interests," he added. Reuters